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Skin Science

Skin is the largest organ of the body and reflects the general state of a person. It is responsible for the protection from external agents (bacteria, chemicals, UV light, mechanical injury), temperature and water loss regulation.

There are many factors that affect skin conditions, such as skin dysbiosis, UV radiation, blue light, lifestyle, environment and pollution. These factors may trigger free radicals and consequently oxidative stress.

Excess of free radicals’ production causes lipid, protein and DNA damage, alteration of cellular proteins and their functions, leading to disruption of vital cellular processes.

When there is an imbalance of free radicals and antioxidant defences, oxidative stress occurs. This imbalance may play a role in skin damage, leading to cell and tissue breakdown. More specifically, triggering free radicals and oxidative stress affect many skin conditions:

  • Acne
  • Atopic Dermatitis
  • Skin aging
  • Skin restoration after a wound
  • Hyperpigmentation
  • Dark circles under the eyes
Skin dysbiosis may further affect the conditions of:

  • Acne and Atopic Dermatitis

    To deal with all the above skin conditions, the New Complete Anivagene Face line is specially designed to offer a holistic approach to all skin needs and problems.

Hair loss

“Am I losing hair?” A person has about 150,000 and 100,000 hairs. We lose about 50 to 100 hairs naturally each day, but if you’re worried, try the “pull” test. Hold around 15 or 20 hairs between thumb and index finger and pull slowly and firmly. If more than six hairs come out, you may have a problem.

Complete range of cosmetic products designed by Aniva International to prevent hair loss and promote natural hair growth. A combination of exclusive active ingredients, extra-gentle dermatologically & clinically tested.

Each hair follows a specific life cycle divided into three phases: Anagen, Catagen and Telogen.

ANAGEN is the phase of active growth and lasts approximately 3-5 years.

CATAGEN is the resting phase where the hair stops growing and lasts about 2-3 weeks.

TELOGEN is the falling phase where the follicle recedes and hair begins to fall in preparation for the development of new hair. The phase lasts approximately 3 months. After the Telogen phase begins the return to the Anagen phase.

On average, approximately 84% of scalp hairs are in the Anagen phase, 1-2% are in the Catagen phase, and 10-15% are in the Telogen phase. To deal with hair loss the Complete Anivagene Hair line is specially designed to offer a holistic approach to hair and scalp problems.


Prebiotics, Probiotics & Postbiotics: the key components to skin protection

Aside of the functional ingredients and Olive oil, Anivagene face line is enriched with Prebiotics, Probiotics and Postbiotics to balance skin microbiota.

Prebiotics: Nutritional elements supporting beneficial bacteria growth that leads to a stronger skin barrier.

Probiotics: Live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Postbiotics: According to *ISAPP definition: ‘A postbiotic is a preparation of inanimate microorganisms and/or their components that confers a health benefit on the host’.


What is Skin microbiota?

  • Skin microbiota, refers to microbiota (communities of microorganisms) that reside on the skin, typically human skin. Many of them are bacteria, found in the superficial layers of the epidermis and the upper parts of hair follicles.
  • Skin microbiota composition depends and it can be changed by intrinsic (age, skin site, ethnicity, gender) and extrinsic (lifestyle, hygiene, cosmetic use, antibiotics, climate) factors.

What is Skin dysbiosis?

  • Changes in composition and lack of balance among microbial communities. It is a condition that may lead to skin diseases (e.g., atopic dermatitis, acne).

Gut -Skin Axis

Gut and Skin are vascularized, with key roles in immune and neuroendocrine systems, colonized by microbial communities. Both organs are crucial for the maintenance of physiologic homeostasis. Recent studies have correlated gut health with skin, hair and nails condition. ​

​More specifically, an unbalanced gut microbiome (dysbiosis), characterized by high colonization of harmful bacteria leads to: ​
  1. High gut permeability (leaky gut) – hair follicles are exposed to antigenic / immune damage​
  2. Gut inflammation – increased circulation of pro-inflammatory cytokines that reach the skin and the hair follicles and impact to hair growth cycle​
  3. Malabsorption – poor nutrient assimilation due to a dysfunctional gut detracts from metabolic processes involved in hair synthesis


Lately, more and more people are looking for not only improve their appearance, but also improve their health condition. Nutricosmetics have been developed to keep up with this demand. Nutricosmetics refer to a combination of nutrients, minerals, vitamins and antioxidants to enhance the appearance and health of skin, hair and nails from within, offering a holistic approach to beauty and well-being. Focusing on nutrition, nutricosmetics aim to improve beauty and health from the inside out. Usually, nutricosmetics come in form of dietary supplements like tablets, capsules or powder for oral administration.

The main benefits of Nutricosmetics, include:
  • Skin health improvement: Ingredients such as vitamins and antioxidants help to maintain the skin hydrated and protected from dryness and free radicals.
  • Hair and scalp health improvement: Ingredients like vitamins and proteins help to strengthen the hair, to prevent hair loss and to improve the microcirculation of the scalp.
  • Nails’ strengthening: Nutricosmetics rich in vitamins and proteins help to strengthening and prevention of nail breakage.
  • Reduction of signs of skin aging: Several nutricosmetics help to increase collagen synthesis or they offer antioxidant properties. In that way they contribute to the reduction of fine lines, wrinkles or dark spots of the skin.

Artificial Intelligence (AI) meets Clinical studies in dermatology

Artificial intelligence (AI) is the simulation of human intelligence processes by machines, especially computer systems. Applications of AI include language translation, image recognition, e-commerce and various other domains.

Nowadays AI technology is widely used throughout industry, government, and science.

With the help of AI technology, clinical studies for the ANIVAGENE ACN-BIOTIC cream and ANIVAGENE VIALS FORTYFYING & ENREGIZING FOR HAIR were conducted.

During the clinical studies, the AntiOxidant Power (AOP) approach was used.

The AOP approach is based on a unique technology which measures antioxidant effects on live cells. This technology called LUCS (Light Up Cell System) originates in a fluorescence assay whose intimate mechanisms were deciphered at the intracellular level in the recent years (2015-2017).

The LUCS technology process was published in the international journal Nature (on-line version, Scientific Reports), on December 22nd 2017 (ref : https://www.nature.com/articles/s41598-017-18211-2.pdf).

Through data science, AOP aims to build the world’s largest intelligent database of proprietary scientific information on antioxidants, enabling the deployment of predictive tools and providing access to personalized medicine.